New opportunity

Senior Applied AI Engineer

Hologic · Marlborough, United States

About this role

The Senior Applied AI Engineer identifies and delivers practical AI solutions across Hologic, from business discovery and feasibility assessment through development, deployment, adoption, and improvement. The role combines stakeholder-facing work with hands-on engineering and requires ownership of projects that may begin as loosely defined problems.

Responsibilities

  • Meet with business teams to discover and prioritize opportunities, map existing processes, define problems and success measures, and turn ideas into actionable options and plans. Be candid when AI is not the right solution.
  • Design and build copilots, agents, retrieval-augmented generation (RAG) applications, and workflow automations using platforms including Azure OpenAI, Claude, and Microsoft Copilot. Choose between custom code and low-code tools such as Power Automate and Logic Apps according to the problem.
  • Integrate solutions with enterprise systems, data, and APIs. Apply version control, testing, CI/CD, and AI-output evaluation; work with security, architecture, governance, and compliance teams to prepare solutions for production.
  • Manage trade-offs involving cost, performance, reliability, and maintainability. Monitor use and value, incorporate feedback, support adoption through training and change support, document decisions, and coach teammates.

Requirements

A bachelor's degree in a technical field or equivalent practical experience; five to eight years in software, solutions, data, or ML engineering, including at least two years building AI, ML, or automation solutions. Candidates need programming ability in Python, JavaScript/TypeScript, C#, or a similar language; knowledge of LLMs, RAG, agents, prompt engineering, and evaluation; and practical familiarity with Claude, OpenAI, Gemini, and leading open-source models. Hands-on Azure application development and deployment, including APIs, cloud services, and authentication, is required, as are stakeholder requirements discussions, success-measure definition, end-to-end project ownership, and communication with technical and business audiences.

Preferred

Experience in Quality or Commercial applications; production agents, RAG applications, or copilots; LangGraph, Semantic Kernel, or Model Context Protocol; Power Platform; containerization, monitoring, observability, and production support; business analysis, consulting, or product management; or regulated environments.

The role is hybrid in Marlborough, Massachusetts, with three days in the office. The stated salary is $94,300k to $147,400k; the final offer depends on experience, skills, and internal pay structures. Benefits include a 401(k) and insurance.

For full details about this role, click “Apply on company site” to view the employer’s original posting.

Skills for this role

PythonJavaScriptTypeScriptC#AzureAzure OpenAIClaudeMicrosoft CopilotGeminiLarge Language ModelsRetrieval-Augmented GenerationAI AgentsPrompt EngineeringAI EvaluationPower AutomateLogic AppsAPIsAuthenticationCI/CDVersion ControlTestingLangGraphSemantic KernelModel Context ProtocolPower PlatformContainerizationMonitoringObservabilityRequirements GatheringStakeholder Management

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Get interview-ready for this role

A focused preparation guide, built around this job’s responsibilities and requirements.

✦ AI-generated guide
Preparation suggestions, not the employer’s actual interview questions. Always check the original posting for current requirements.
01

Understand the role

What matters most

  • Define the right problem and measure of success

    The role starts with business discovery: map current processes, prioritize opportunities, define success measures, and say when AI is not the right answer.

  • Build solutions that fit the problem

    Design copilots, agents, RAG applications, and automations; choose between custom code and tools such as Power Automate or Logic Apps based on the use case, not the novelty of the tool.

  • Deliver production-ready solutions on Azure

    Integrate with enterprise systems, data, and APIs on Hologic’s Azure infrastructure. Apply authentication, security, testing, CI/CD, and AI-output evaluation while working with architecture, governance, and compliance teams.

  • Own outcomes beyond deployment

    Stay with projects through rollout and improvement: monitor use and value, gather feedback, support training and adoption, and weigh cost, performance, reliability, and maintainability.

  • Make decisions understandable and reusable

    Explain AI capabilities, limits, risks, and trade-offs to business and technical audiences, including senior leaders. Document decisions, review designs, and coach teammates.

Likely challenges to think through

  • Turning ambiguity into a defensible plan

    Likely preparation challenge: projects may begin without a written specification, while stakeholders need actionable options. Prepare a concise example of mapping a process, testing whether AI adds value, and agreeing on measurable success before building.

  • Choosing an approach without overengineering

    Likely preparation challenge: a custom agent or RAG application may offer flexibility, while a simpler automation may be easier to maintain. Prepare to explain how you would compare options using output quality, integration needs, cost, and operational complexity.

  • Balancing AI quality with production constraints

    Likely preparation challenge: improving an AI output may affect cost, latency, or reliability, while enterprise integrations require security and governance review. Prepare an example of evaluation criteria, testing, monitoring, and a trade-off explained in business terms.

  • Converting deployment into sustained use

    Likely preparation challenge: a technically working solution may not deliver value if teams do not adopt it. Prepare to describe how you would use training, feedback, usage measures, and follow-up improvements to assess the outcome.

03

Practice your answers

Technical practice

How would you decide whether a loosely defined business problem warrants an AI solution?

What to coverThe role involves mapping current processes, prioritizing opportunities, and defining success measures before proposing a solution. Suggested preparation: explain how you would clarify the problem, compare AI with simpler options, and agree on measurable outcomes.

How would you design and evaluate a retrieval-augmented generation application?

What to coverThe posting names RAG applications, enterprise data integration, and AI-output evaluation. Suggested preparation: discuss retrieval quality, source relevance, answer quality, and how evaluation results would guide improvements.

When would you use an agent, a copilot, or workflow automation?

What to coverThe role builds all three types of solution and emphasizes choosing the approach that fits the problem. Suggested preparation: compare the level of autonomy, integration needs, reliability, and support burden of each.

How would you choose a model and refine its prompts for a business use case?

What to coverThe posting asks for practical familiarity with Claude, OpenAI, Gemini, and leading open-source models, as well as prompt engineering. Suggested preparation: describe a comparative evaluation using task quality, cost, performance, and limitations rather than assuming one model is best.

How would you choose between custom code and Power Automate or Logic Apps?

What to coverThe role explicitly calls for choosing between programming and low-code configuration. Suggested preparation: weigh integration complexity, maintainability, testing, delivery speed, and the needs of the team that will support the solution.

How would you integrate an AI application with enterprise systems on Azure?

What to coverHands-on Azure deployment, APIs, cloud services, authentication, and security from the start are stated requirements. Suggested preparation: outline the application boundaries, data and API access, authentication approach, and how you would test the integration.

How would you bring AI-output evaluation into a development and release workflow?

What to coverThe posting calls for version control, testing, CI/CD, and evaluation of output quality. Suggested preparation: distinguish conventional software tests from AI-output checks and explain how findings would inform changes before and after release.

What would you address before moving an AI solution into production?

What to coverThe role works with security, architecture, governance, and compliance teams to prepare solutions for production. Suggested preparation: describe how you would surface risks, document design decisions, and resolve concerns with those teams without assuming a particular approval process.

How would you explain cost, performance, reliability, and maintainability trade-offs?

What to coverThe posting asks the engineer to weigh these trade-offs and explain them in plain business terms. Suggested preparation: compare plausible solution options and show how you would make the consequences of each choice clear to leaders and engineers.

How would you tell whether a deployed solution is being used and delivering value?

What to coverThe role includes monitoring, feedback loops, adoption support, and improvement after deployment. Suggested preparation: connect usage and quality signals to the success measures agreed during discovery, then explain how feedback would shape the next iteration.

Behavioural practice

Tell me about a time you took ownership of an ambiguous problem.

What to coverThe role expects projects to move forward without a written specification or close direction. Suggested preparation: use a real situation, your actions to clarify the problem and define success, and the resulting outcome.

Describe a time you advised against a proposed technical solution.

What to coverThe posting explicitly asks for honesty when AI is not the right answer. Suggested preparation: give a real example of the situation, how you explained your reasoning to stakeholders, and what resulted.

Tell me about a time you worked across teams to make a solution production-ready.

What to coverThe role involves collaboration with security, architecture, governance, and compliance teams. Suggested preparation: describe the situation, your actions to address differing concerns, and the result without implying you followed Hologic's processes.

Describe a time you helped people adopt a solution after launch.

What to coverThe posting includes training, feedback sessions, change support, and continued improvement. Suggested preparation: give a real situation, the actions you took in response to users' needs, and evidence of the result.

Tell me about a time you coached teammates or explained a complex decision to different audiences.

What to coverThe role includes coaching, design reviews, documentation, and communication with business and technical audiences. Suggested preparation: focus on one real situation, how you adapted your communication or coaching, and what changed as a result.

02

Sharpen your knowledge

Topics to prepare

  • AI opportunity assessment

    The role starts with vague business problems and requires honesty about when AI will not help. Revise by comparing AI, conventional automation, and process-change options for a hypothetical workflow; state assumptions, risks, and measurable success criteria.

  • LLM application patterns

    Working knowledge of LLMs, RAG, agents, prompt engineering, and evaluation is required. Revise by explaining when a copilot, retrieval-based answer, agent, or simple workflow automation fits a problem, and how you would evaluate its output.

  • Model and implementation trade-offs

    The posting calls for a practical view of Claude, OpenAI, Gemini, and leading open-source models, plus choices between custom code and low-code platforms. Revise by making a comparison table for one hypothetical use case covering suitability, cost, performance, reliability, and maintainability; treat conclusions as case-dependent.

  • Enterprise production readiness

    Solutions must integrate with systems, data, and APIs on Hologic’s Azure infrastructure and involve security, architecture, governance, and compliance teams. Revise by sketching an application boundary and listing the authentication, data-access, testing, and review questions to resolve before deployment.

  • Outcome ownership and adoption

    The engineer owns projects through deployment, use, support, and improvement. Revise by outlining how usage, value, feedback, training, and design documentation would inform the next iteration of a hypothetical solution.

Skills to revise

  • Run a discovery conversation

    Practice a mock stakeholder interview: map the current process, clarify the underlying problem, define success measures, and present options in language suitable for both leaders and engineers. These are explicit duties in the posting.

  • Prototype and evaluate RAG

    As a preparation exercise, build a small RAG prototype over sample documents, write representative questions, inspect retrieved evidence, and score answer quality and failures. RAG development and AI-output evaluation are explicit parts of the role.

  • Integrate an Azure application

    Practice implementing a small application in a posting-listed language that calls an API, handles authentication, and can be deployed on Azure. Hands-on Azure development, integration, cloud services, and authentication are required.

  • Apply engineering controls

    Put a small AI application under version control; add tests, an output-evaluation set, and a CI/CD check. The posting explicitly calls for version control, testing, CI/CD, and evaluation.

  • Choose code or workflow configuration

    Sketch the same automation using custom code and using Power Automate or Logic Apps, then justify the choice and its maintenance trade-offs. The role explicitly calls for selecting the approach that fits the problem.

  • Plan monitoring and adoption

    For a hypothetical deployed copilot, draft a usage-and-value dashboard outline, a feedback collection plan, and a short user-training agenda. Monitoring, feedback, and change support are stated responsibilities; the hypothetical plan is a practice exercise.

04

Your preparation checklist

  • Draft a discovery brief

    The role starts with loosely defined business problems. As preparation, write a sample process map, problem statement, success measures, prioritized options, and a case for when AI would not help.

  • Prepare an end-to-end project walkthrough

    The posting emphasizes ownership through deployment and adoption. Select a project you can discuss and prepare a concise account of the problem, decisions, implementation, release, feedback, and measured outcome; distinguish your own work from the team's.

  • Practice an AI solution design exercise

    The role builds copilots, agents, RAG applications, and automations. Sketch one example architecture, explaining why you would choose RAG, an agent, a simpler automation, or no AI, and when custom code beats Power Automate or Logic Apps.

  • Assemble Azure engineering evidence

    Hands-on Azure development and deployment, APIs, authentication, version control, testing, and CI/CD are stated expectations. Prepare an architecture diagram or code excerpts you are permitted to share, with notes on integration and security decisions.

  • Build an evaluation and model-choice plan

    The posting calls for AI-output evaluation and a practical view of Claude, OpenAI, Gemini, and open-source models. Prepare sample test cases, quality and failure measures, and a comparison that addresses cost, performance, reliability, and maintainability.

  • Outline a production and adoption plan

    The role works with security, architecture, governance, and compliance teams and tracks use and value after launch. As preparation, draft a review checklist covering monitoring, feedback, support, documentation, training, and improvement.

  • Write focused questions for the employer

    Prepare questions about how opportunities are prioritized, what production reviews involve, how adoption and value are measured, and where the team most needs reusable AI patterns. These are questions to ask, not assumptions about Hologic's processes.

AI-generated from the job information · Prepared Sep 30, 2026 (UTC)Useful preparation, not a guarantee of eligibility or an offer.

Availability last checked: Nov 4, 2026. Status can change after a check; confirm on the employer’s website. Report an issue · Our checking policy

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