New opportunity

Principal Machine Learning Operations Engineer

Definitive Healthcare · Framingham, United States

About this role

Definitive Healthcare seeks a hands-on Principal Machine Learning Operations Engineer to lead the design and scaling of secure, automated infrastructure for traditional predictive models and generative and agentic AI systems. As functional lead, the engineer will set MLOps practices and translate business objectives into production pipelines for the healthcare data and analytics business.

Responsibilities

  • Design and maintain scalable ML and data pipelines for CI/CD, model training and deployment. Architect enterprise feature stores and vector stores for low-latency retrieval supporting predictive ML and retrieval-augmented generation (RAG).
  • Build workflow orchestration for multi-stage training and data processing. Develop infrastructure for LLM applications, RAG pipelines and multi-agent workflows, including environments for training and parameter-efficient fine-tuning of open-source and proprietary models.
  • Optimize high-throughput, low-latency inference through caching and distributed compute. Use model registries to govern versioning, lineage and tracking from experimentation to production. Design cost-efficient AWS infrastructure with autoscaling, and monitor model performance, data drift, endpoint latency and system health in real time.
  • Define coding standards, architectural blueprints, framework choices and operational SLAs. Provide technical guidance, code reviews and mentorship to senior machine learning and data engineers.

Qualifications

  • Bachelor’s or master’s degree in computer science, computer engineering, data science or a closely related quantitative engineering discipline.
  • At least 12 years of professional experience in data engineering or ML engineering, including a minimum of 5 years building, scaling and managing production MLOps platforms.
  • Hands-on production architecture experience with Databricks and native AWS environments; expert Python proficiency and production experience deploying TensorFlow and PyTorch models.

Compensation and benefits: Base salary is $158,000–$294,000 per year, with actual pay based on experience, skills and qualifications. Depending on the position, employees may be eligible for a bonus or commission plan. Benefits include medical, dental and vision coverage, unlimited paid time off and a 401(k) plan with employer contribution.

For full details about this role, click “Apply on company site” to view the employer’s original posting.

Skills for this role

MLOpsMachine LearningGenerative AIPythonDatabricksAWSTensorFlowPyTorchCI/CDData PipelinesFeature StoresVector StoresRetrieval-Augmented GenerationLarge Language ModelsAI AgentsWorkflow OrchestrationModel TrainingModel Fine-TuningModel InferenceModel RegistriesModel MonitoringData Drift MonitoringAutoscalingTechnical LeadershipCode ReviewMentorship

Your skill match

Checking your profile…

YOUR NEXT STEP

Get interview-ready for this role

A focused preparation guide, built around this job’s responsibilities and requirements.

✦ AI-generated guide
Preparation suggestions, not the employer’s actual interview questions. Always check the original posting for current requirements.
01

Understand the role

What matters most

  • Build a unified production ML platform

    The role calls for secure, automated pipelines for CI/CD, data processing, model training and deployment across predictive ML and generative AI. Prepare to explain architecture decisions spanning Databricks and native AWS.

  • Govern retrieval and model lifecycles

    The posting assigns ownership of enterprise feature and vector stores for low-latency retrieval, plus model-registry policies for versioning, lineage and tracking from experimentation to production.

  • Scale generative and agentic AI infrastructure

    The engineer will build frameworks for LLM applications, RAG and multi-agent workflows, and environments for training and parameter-efficient fine-tuning of open-source and proprietary models.

  • Deliver efficient, observable inference

    The role emphasizes high-throughput, low-latency inference using caching and distributed compute, cost-efficient AWS autoscaling, and real-time monitoring of model performance, drift, latency and system health.

  • Set technical direction while remaining hands-on

    As functional lead, the engineer defines coding standards, architecture, framework choices and operational SLAs while providing code reviews, guidance and mentorship to senior engineers.

Likely challenges to think through

  • One platform, different workload patterns

    Preparation hypothesis: predictive models, RAG and agent workflows may need different retrieval, orchestration and deployment patterns without fragmenting the platform. Prepare an architecture example that distinguishes shared controls from workload-specific components.

  • Latency and throughput versus infrastructure cost

    Preparation hypothesis: concurrent inference and variable training demand could make always-on capacity expensive, while aggressive scaling or caching could affect responsiveness. Prepare to explain how you would measure the trade-off and choose autoscaling, caching and compute distribution approaches.

  • Traceability versus delivery speed

    Preparation hypothesis: registry policies, lineage and monitoring add controls to fast-moving experiments and multi-stage pipelines. Prepare an example of how automated checks and clear promotion criteria could preserve traceability without relying on manual handoffs.

  • Standards versus team autonomy

    Preparation hypothesis: setting frameworks and SLAs while mentoring senior engineers may require consistency without blocking sound local decisions. Prepare to describe how you would document architectural choices, review exceptions and use code reviews to guide adoption.

03

Practice your answers

Technical practice

How would you design a CI/CD pipeline for deploying predictive models built in TensorFlow or PyTorch?

What to coverThe role calls for scalable ML and data pipelines, Python proficiency, and production deployment of TensorFlow and PyTorch models. Preparation suggestion: explain how you would validate code and models, promote releases, and handle rollback in Databricks and native AWS environments.

How would you architect feature and vector stores for low-latency retrieval?

What to coverThe posting calls for governing both stores to support traditional ML and RAG applications. Preparation suggestion: compare their retrieval needs and explain how you would manage freshness, consistency, and latency.

How would you orchestrate a multi-stage training and data-processing workflow?

What to coverThe role includes scheduling, monitoring, and managing complex workflow dependencies. Preparation suggestion: describe dependency handling, failure recovery, and how you would tell whether a run completed correctly.

How would you build infrastructure for RAG and multi-agent applications?

What to coverThe posting names scalable frameworks for LLM applications, RAG pipelines, and multi-agent workflows. Preparation suggestion: distinguish retrieval, generation, and agent coordination, then discuss how you would evaluate reliability and control operational complexity.

How would you choose an approach to training or parameter-efficient fine-tuning?

What to coverThe role includes environments for training and parameter-efficient fine-tuning of open-source and proprietary models. Preparation suggestion: explain the trade-offs you would examine, including compute cost, model quality, and deployment constraints, without assuming a particular model is in use.

How would you improve inference throughput without losing sight of latency?

What to coverThe posting calls for caching and distributed compute to handle large-scale concurrent requests. Preparation suggestion: describe where caching could help, what could make cached results unsuitable, and how you would measure throughput and latency together.

What policies would you establish for a production model registry?

What to coverThe role calls for version control, lineage, and tracking from experimentation to production. Preparation suggestion: explain what you would record for a model release and how that record would support promotion, investigation, and rollback.

How would you design cost-efficient AWS capacity for varying ML workloads?

What to coverThe posting specifies AWS autoscaling for changing training and inference demand. Preparation suggestion: compare the capacity needs of those workloads and explain how you would balance cost, response time, and available compute.

How would you investigate deteriorating model or endpoint performance?

What to coverThe role includes real-time monitoring of model performance, data drift, latency, and system health. Preparation suggestion: walk through how you would use those signals to separate a data or model issue from an infrastructure issue and decide what to address first.

How would you select frameworks and define operational standards for a unified AI platform?

What to coverAs functional lead, this engineer defines architectural blueprints, framework choices, coding standards, and operational SLAs for a secure AI ecosystem. Preparation suggestion: explain how you would evaluate alternatives and make the resulting standards practical for predictive and generative systems.

Behavioural practice

When did you turn a business objective into a production ML pipeline?

What to coverThe role involves translating strategic objectives into scalable automated pipelines. Preparation suggestion: use a real situation, the decisions and actions you took to define the work, and the resulting operational or business outcome.

When did you guide senior engineers through a difficult technical decision?

What to coverThe posting calls for technical guidance, code reviews, and mentorship of senior ML and data engineers. Preparation suggestion: describe the situation, how you offered guidance while incorporating their input, and what changed as a result.

When did you establish an engineering standard across multiple teams?

What to coverThe functional lead is expected to set MLOps practices, coding standards, and architectural blueprints. Preparation suggestion: give a real example of the starting inconsistency, your actions to build adoption, and the observable result.

When did you resolve a production ML reliability issue under pressure?

What to coverThe role owns monitoring, model deployments, and operational SLAs. Preparation suggestion: recount the situation, how you prioritized diagnosis and communication, and the result, including any follow-up improvement.

When did you balance delivery speed against infrastructure cost or performance?

What to coverThe posting emphasizes cost-efficient AWS infrastructure and high-throughput, low-latency inference. Preparation suggestion: use a real situation to explain the competing priorities, your decision and actions, and the measured or observed outcome.

02

Sharpen your knowledge

Topics to prepare

  • Production MLOps architecture

    The posting calls for a secure, automated ecosystem for predictive and generative models, with production architecture in Databricks and native AWS. Revise by sketching how data, training, CI/CD, deployment, and access boundaries fit together; explain your scaling and security trade-offs.

  • Feature and vector store design

    The role governs enterprise feature and vector stores for low-latency predictive-ML and RAG retrieval. Revise by comparing their data models, update paths, and retrieval-latency trade-offs in a proposed architecture.

  • LLM and agentic workflow architecture

    The posting names LLM applications, RAG, multi-agent workflows, and parameter-efficient fine-tuning. Revise by diagramming when retrieval, fine-tuning, or an agent workflow serves a use case, and where training and processing dependencies arise.

  • Inference capacity and cost

    The role emphasizes concurrent, low-latency inference, caching, distributed compute, and AWS autoscaling groups. Revise by working through a traffic-spike scenario and explaining the latency, throughput, and infrastructure-cost trade-offs.

  • Model governance and observability

    The posting specifies registry-based versioning, lineage, experiment-to-production tracking, and real-time monitoring of performance, drift, latency, and system health. Revise by tracing a model release from experiment to rollback and identifying the signals that would prompt investigation.

  • Functional-lead decisions

    This principal role sets coding standards, architectural blueprints, framework choices, and operational SLAs while mentoring senior engineers. Revise by preparing a decision framework for choosing a shared pipeline standard and explaining how you would review exceptions and communicate trade-offs.

Skills to revise

  • Build an orchestrated ML pipeline

    The posting requires scalable data and ML pipelines, CI/CD, and orchestration of multi-stage dependencies. Practice outlining or implementing a small pipeline with data processing, training, checks, and deployment stages, then demonstrate how a failed stage is detected and retried.

  • Deploy Python models

    Expert Python and production deployment of TensorFlow and PyTorch models are explicit qualifications. Practice packaging one model from each framework behind an inference interface, with versioned inputs, error handling, and a deployment check.

  • Implement retrieval paths

    The role calls for feature-store and vector-store infrastructure supporting predictive models and RAG. Practice building a small feature lookup and a separate retrieval-to-generation flow; measure lookup latency and explain how updates reach each store.

  • Prototype fine-tuning and agent workflows

    The posting calls for environments for parameter-efficient fine-tuning and frameworks for multi-agent workflows. As a preparation exercise, sketch a minimal fine-tuning run and a multi-step agent workflow, including dependency tracking and failure handling; these particular prototypes are suggestions, not stated employer assignments.

  • Test inference scaling and monitoring

    AWS autoscaling, caching, distributed compute, and real-time endpoint monitoring are stated responsibilities. Practice a load-test plan for varying request volumes and define measurements for latency, throughput, model performance, drift, and system health.

  • Conduct an architecture and code review

    The functional lead provides code reviews and guidance to senior engineers. Practice reviewing a proposed pipeline change for maintainability, lineage, operational SLA impact, and deployment risk; write concise feedback that separates required fixes from design choices.

04

Your preparation checklist

  • Map evidence to the stated qualifications

    Prepare a one-page evidence map for the role’s degree, 12+ years in data or ML engineering, 5+ years building production MLOps platforms, and hands-on Databricks, native AWS, Python, TensorFlow, and PyTorch experience. Note concrete examples rather than assuming a match.

  • Build a production-platform walkthrough

    Prepare a diagram and brief narrative of a relevant platform you worked on, covering data and ML pipelines, CI/CD, deployment, workflow orchestration, and the decisions made to scale it. The role explicitly calls for hands-on architecture and automated pipelines.

  • Practice a feature-and-retrieval design exercise

    Sketch a proposed architecture for governed feature and vector stores serving predictive ML and low-latency RAG retrieval. Label it as a proposed design, and be ready to explain freshness, latency, and governance trade-offs.

  • Prepare a generative-AI infrastructure discussion

    Outline how you would support LLM applications, RAG, multi-agent workflows, and parameter-efficient fine-tuning. Include a proposed way to test the design and compare open-source and proprietary model options; these are preparation ideas, not stated company practices.

  • Show how you would operate models in production

    Prepare an example or proposed plan covering model registry versioning and lineage, AWS autoscaling, caching or distributed inference, and monitoring for model performance, drift, latency, and system health. Explain the cost and reliability trade-offs.

  • Document functional-lead decisions

    Prepare two examples of setting engineering standards or architectural direction and guiding senior engineers through reviews or mentorship. For each, state the decision, trade-offs, and observed outcome; the posting assigns these responsibilities to the functional lead.

  • Draft questions for the employer

    Bring questions about current Databricks and AWS architecture, priorities for predictive versus generative AI, feature and vector store ownership, operational SLAs, and how the functional lead works with senior engineers. These are questions to investigate, not claims about existing systems.

AI-generated from the job information · Prepared Sep 30, 2026 (UTC)Useful preparation, not a guarantee of eligibility or an offer.

Availability last checked: Nov 4, 2026. Status can change after a check; confirm on the employer’s website. Report an issue · Our checking policy

KEEP EXPLORING

Similar AI jobs

Related skills and specializations in United States. Matched to this role, not your profile.

Explore more jobs
Finding similar opportunities…